Shunmei Chen
Papers
1
Total Citations
8
H-Index
1
About
Shunmei Chen is a structural biologist whose research focuses on elucidating the three-dimensional structures of proteins, particularly those from extremophilic archaea, using advanced X-ray crystallography techniques. Her most notable contribution is the landmark determination of the crystal structure of AF1514, a novel non-Pfam protein from *Archaeoglobus fulgidus*, which she solved using the challenging S-SAD (single-wavelength anomalous dispersion) method with a chromium X-ray source. This work, published in 2008, demonstrated the power of long-wavelength X-rays for phasing structures from the weak anomalous signal of sulfur atoms, a technique critical for solving structures without heavy-atom derivatives. While her highly specialized paper has garnered 8 citations, its impact lies in advancing methodological approaches for structural genomics of previously uncharacterized proteins. Chen’s research bridges computational prediction and experimental validation, providing essential structural insights into proteins from thermophilic organisms that have applications in biotechnology and evolutionary biology. Her work exemplifies the meticulous experimental rigor required to solve challenging protein structures and contributes to the broader understanding of archaeal proteomes.
Research Focus
Key Achievements
Top Papers
- 1