Yirong Jiang
Papers
2
Total Citations
75
H-Index
2
About
Yirong Jiang is a trailblazer in single-cell proteomics, a field that seeks to decode the protein landscape of individual cells—a critical frontier for understanding tumor biology and cellular heterogeneity. Her major contribution is the development of the **Pick-up Single-Cell Proteomic Analysis (PiSPA)** workflow, a groundbreaking method that dramatically expands the depth of single-cell protein identification. While conventional shotgun proteomic analysis typically identifies only ~1,000 proteins per cell—insufficient for many biological applications—Jiang’s PiSPA technique achieves quantification of up to **3,000 proteins in a single mammalian or tumor cell**, as demonstrated in her highly cited 2024 paper (66 citations) and its 2022 precursor (9 citations). This leap in sensitivity and coverage opens new doors for dissecting rare cell populations, drug resistance mechanisms, and early disease markers. By pushing the boundaries of single-cell protein sequencing, Jiang’s work has the potential to transform precision oncology and cellular biology, providing researchers with a powerful tool to explore the proteomic complexity hidden within individual cells. Her innovative approach marks a significant step toward making single-cell proteomics as routine and informative as single-cell genomics.
Research Focus
Key Achievements
Top Papers
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