Wei-Xin Ying
Papers
2
Total Citations
75
H-Index
2
About
Wei-Xin Ying is a pioneering researcher in the field of single-cell proteomics, with a primary focus on advancing the sensitivity and throughput of protein sequencing technologies. His most significant contribution is the development of the **Pick-up Single-Cell Proteomic Analysis (PiSPA)** workflow, a groundbreaking method that dramatically increases the number of proteins identifiable from a single mammalian cell. While conventional shotgun proteomic analysis was limited to roughly 1,000 proteins per cell, Ying’s PiSPA technique has successfully quantified up to **3,000 proteins** in a single tumor cell, as demonstrated in his highly cited 2024 paper (66 citations). This represents a threefold improvement, pushing the boundaries of what is possible in single-cell biology. By enabling such deep proteomic coverage, Ying’s work provides an unprecedented window into cellular heterogeneity, with profound implications for cancer research, biomarker discovery, and personalized medicine. His 2022 foundational paper (9 citations) laid the groundwork for this breakthrough. Ying’s achievements place him at the forefront of a critical technological race, making him a key figure for any student or researcher interested in the future of single-cell analysis and the quest to understand the proteome at the ultimate resolution.
Research Focus
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Top Papers
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