Qian‐Xi Fan
Papers
2
Total Citations
75
H-Index
2
About
Qian‐Xi Fan is a pioneering researcher in single-cell proteomics, a field focused on decoding the protein landscape of individual cells to understand biological heterogeneity at the molecular level. Her major contributions center on developing the "pick-up single-cell proteomic analysis" (PiSPA) workflow, a groundbreaking method that dramatically advances the sensitivity and depth of single-cell protein sequencing. While conventional shotgun proteomic approaches typically identify only around 1,000 proteins per cell—insufficient for many practical applications—Fan’s PiSPA technique achieves quantification of up to 3,000 proteins in a single mammalian cell, as demonstrated in her 2024 paper, which has already garnered 66 citations. This work, along with a 2022 study applying PiSPA to tumor cells (9 citations), represents a significant leap in analytical capability, enabling more comprehensive insights into cellular function, disease mechanisms, and therapeutic targets. Fan’s innovations are pivotal for the future of precision medicine and systems biology, offering researchers a powerful tool to explore the proteomic complexity of individual cells with unprecedented resolution.
Research Focus
Key Achievements
Top Papers
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