Wencheng Xiao

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About

Wencheng Xiao is a pioneering researcher at the forefront of nanomedicine and targeted cancer therapy, with a particular focus on bladder cancer treatment. His most notable contribution involves the development of anti-biopassivated reticular micromotors, which address a critical limitation in enzyme-powered micro/nanomotors (MNMs)—their rapid deactivation within tumor microenvironments. By ingeniously leveraging hydrogen bond-rich metal-organic frameworks (MOFs), Xiao designed urease-powered MOF motors that maintain sustained propulsion and therapeutic efficacy, overcoming biological barriers that typically hinder MNM performance. This breakthrough work, published in 2025 and already garnering 10 citations, demonstrates his ability to solve fundamental challenges in drug delivery systems. Xiao’s research elegantly combines materials science, enzymology, and oncology, offering a transformative approach to bladder cancer therapy by enabling active, self-propelled drug carriers that can penetrate deep into tumors. His innovative strategy not only extends the operational lifespan of micromotors but also opens new avenues for precision medicine, positioning him as an emerging leader in the field of nanorobotics for biomedical applications.