Hang Ao

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About

Hang Ao is a rising figure in nanomedicine, specializing in the design of enzyme-powered micro/nanomotors (MNMs) for targeted cancer therapy. Their work addresses a critical bottleneck in the field: the rapid deactivation of these tiny motors within the hostile tumor microenvironment. In their landmark 2025 study, "Anti-biopassivated Reticular Micromotors for Bladder Cancer Therapy," Ao pioneered a novel approach using hydrogen bond-rich metal-organic frameworks (MOFs) to create anti-biopassivated, urease-powered motors. This breakthrough significantly extends the operational lifespan of MNMs, overcoming the long-standing challenge of enzymatic deactivation. Already garnering 10 citations shortly after publication, this work has quickly captured the attention of the nanorobotics and drug delivery communities. By engineering a protective MOF shell that preserves enzyme activity, Ao’s research opens a promising new avenue for the practical application of micromotors in bladder cancer and other solid tumors, marking them as an innovator to watch in the quest for next-generation, self-propelling therapeutic agents.