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About

Ugo Gradilone is a urologic surgeon and researcher whose work centers on advancing the surgical management of kidney stone disease. His primary research areas include minimally invasive stone surgery, laser lithotripsy technology, and comparative effectiveness of robotic versus percutaneous approaches. Dr. Gradilone’s major contribution is his rigorous comparative analysis of percutaneous nephrolithotomy (PCNL) and robotic pyelolithotomy (RPL) for large renal stones, using advanced statistical methods like inverse probability treatment weighting to address selection bias. This work, published in 2025 with 9 citations, provides critical evidence for surgical decision-making in complex stone cases. He has also contributed to the technical optimization of laser lithotripsy, conducting a standardized robotic comparison of Ho:YAG, Thulium Fiber Laser (TFL), and pulsed Tm:YAG ablation rates. This study, with 3 citations, offers practical insights into laser selection for efficient stone fragmentation. Dr. Gradilone’s research bridges the gap between emerging robotic techniques and established endoscopic approaches, helping to define best practices for large stone management. His work is particularly valuable for urologists seeking to minimize complications while maximizing stone-free rates in challenging clinical scenarios.