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About

Samantha Cipressi is a leading medical physicist and radiation oncology researcher whose work centers on stereotactic body radiotherapy (SBRT) for challenging anatomical sites, including cardiac malignancies and abdominal lymph node metastases. Her most cited paper, "Stereotactic Body Radiotherapy with Cyberknife for Cardiac Malignancies" (2015, 23 citations), broke new ground by demonstrating the feasibility of delivering focused, high-dose radiation to primary and secondary cardiac tumors—a region traditionally considered off-limits due to radiobiological and technical constraints. This work has helped expand the therapeutic frontier for patients with few other options. Cipressi also made significant contributions to treatment planning optimization, as seen in her 2020 study (17 citations) assessing a novel optimization system for robotic SBRT with multileaf collimators, directly improving plan quality and delivery efficiency. Her 2013 paper on SBRT for abdominal lymph node metastases (17 citations) further established her expertise in image-guided, linac-based and robotic approaches, reporting promising clinical outcomes across diverse primary cancers. With a career defined by technical innovation and clinical translation, Cipressi’s research continues to shape the safe, effective application of SBRT in previously inoperable or radioresistant settings.