Richard C. Francis
Papers
1
Total Citations
5
H-Index
1
About
Richard C. Francis is a researcher whose work centers on cellular signaling mechanisms, particularly the mitogenic pathways activated by angiotensin II (AII) in adrenal and other tissues. His most cited study, "The Application of High Density Microarray for Analysis of Mitogenic Signaling and Cell-Cycle in the Adrenal" (2000), with 5 citations, explores how AII binds to G-protein coupled receptors—specifically the AT1 subclass—to drive proliferation in the H295R human adrenocortical cell line. This work contributes to understanding how hormonal signals regulate cell growth in adrenal, liver, and vascular smooth muscle cells, with implications for conditions like hypertension and adrenal disorders. While his citation count is modest, Francis’s research provides foundational insights into receptor-mediated mitogenesis, offering a springboard for further studies on cell-cycle control and signaling networks. His focus on microarray technology in the early 2000s also highlights his role in adopting high-throughput methods to dissect complex biological processes, making his contributions valuable for students and researchers exploring endocrine signaling and cellular proliferation.
Research Focus
Key Achievements
Top Papers
- 1