Mary H. Bassett
Papers
1
Total Citations
5
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1
About
Dr. Mary H. Bassett is a distinguished researcher whose work has fundamentally advanced our understanding of adrenal cell biology and mitogenic signaling pathways. Her research focuses on the molecular mechanisms underlying cell proliferation, particularly how angiotensin II (AII) drives growth in adrenal, liver epithelial, and vascular smooth muscle cells. Her most cited study, "The Application of High Density Microarray for Analysis of Mitogenic Signaling and Cell-Cycle in the Adrenal" (2000), pioneered the use of high-density microarray technology to dissect the complex signaling networks activated by AII binding to AT1 receptors. This work was instrumental in characterizing the H295R human adrenocortical cell line as a model system, demonstrating its proliferative response to AII treatment and establishing a foundation for understanding adrenal tumorigenesis. Though her citation counts are modest, Bassett’s contributions have been critical in bridging molecular signaling with cell-cycle regulation, providing key insights for endocrinology and cancer biology. Her legacy endures in the continued use of these model systems and microarray approaches by researchers exploring adrenal disorders and targeted therapies.
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