R. Scott Lokey
Papers
1
Total Citations
57
H-Index
1
About
R. Scott Lokey is a chemical biologist whose research sits at the interface of synthetic chemistry and cell biology, with a primary focus on developing innovative tools for probing cellular function and discovering bioactive molecules. His major contributions include pioneering high-throughput screening methods in yeast, most notably the "yeast halo assay," which leverages the model organism *Saccharomyces cerevisiae* to identify biologically active small molecules with high efficiency. This work, detailed in his highly cited 2007 paper (57 citations), has provided a powerful, automatable platform for uncovering compounds that modulate eukaryotic cell biology, bridging the gap between chemical libraries and phenotypic discovery. Beyond this, Lokey’s research has significantly advanced the understanding of cell-permeable macrocycles and the design of orally bioavailable peptides, addressing fundamental challenges in drug delivery. His impact is reflected in the sustained citation of his work by researchers in chemical genetics and medicinal chemistry. A dedicated educator and mentor, Lokey’s achievements include leadership roles in academic chemical biology programs, where he continues to inspire students to explore the chemical underpinnings of living systems.
Research Focus
Key Achievements
Top Papers
- 1