Karen Tenney
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Total Citations
57
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About
Dr. Karen Tenney is a pioneering chemical biologist whose work sits at the intersection of natural product discovery and high-throughput screening. Her research focuses on developing innovative assays to accelerate the identification of biologically active small molecules, particularly from marine and microbial sources. Her most impactful contribution, the 2007 paper "Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay" (57 citations), introduced a novel, easily automated yeast toxicity screen that transformed how researchers probe eukaryotic cell biology. By adapting the model organism *Saccharomyces cerevisiae* for rapid, large-scale compound testing, Tenney’s method enabled the efficient detection of bioactive molecules with therapeutic potential, bridging the gap between basic cell biology and drug discovery. Her work has been instrumental in streamlining the pipeline from natural product isolation to functional characterization, making her a key figure in the field of chemical genetics and marine natural products chemistry.
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