Papers
2
Total Citations
61
H-Index
2
About
Paul Machillot is a leading researcher at the interface of biomaterials and high-throughput cell biology, whose work is pioneering new ways to engineer cellular microenvironments. His primary research focuses on developing automated, biomimetic coatings and 3D-architected scaffolds to precisely control cell behavior for drug screening and tissue engineering. Machillot’s most significant contribution is the establishment of an automated method for layer-by-layer (LbL) assembly of bioactive films directly in standard cell culture microplates. This breakthrough, detailed in his highly cited 2018 paper (44 citations), enables the high-throughput screening of cellular behaviors on tailored surfaces, a major step forward for drug discovery. Building on this, he has combined these bioactive coatings with 3D-printed microscale scaffolds fabricated via two-photon polymerization. His 2022 work (17 citations) demonstrates a powerful new platform for creating a microscale niche for pancreatic tumor cells, offering a more realistic model for cancer research. By merging automation with advanced biofabrication, Machillot is providing researchers with robust, scalable tools to decode the complex dialogue between cells and their environment.
Research Focus
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Top Papers
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