Pasi Halonen

The Netherlands Cancer Institute, VTT Technical Research Centre of Finland

Papers

Total Citations

H-Index

About

Pasi Halonen is a researcher whose work bridges cancer biology and enzymatic discovery, with key contributions in DNA damage response and high-throughput screening. His most cited study, "Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity" (2017, 32 citations), highlights his role in developing targeted therapies that enhance radiotherapy efficacy. This work identified a small molecule inhibitor of ATM kinase, selectively sensitizing cancer cells to radiation while sparing normal tissue—a promising approach for improving head and neck cancer treatment. Halonen’s expertise in assay development is further demonstrated in "A high throughput profiling method for cutinolytic esterases" (2009, 13 citations), where he co-developed a robust platform for characterizing esterase activity, relevant to biotechnology and biocatalysis. Though his citation counts reflect focused contributions, his impact lies in advancing precision oncology and enzymatic screening tools. Halonen’s collaborative efforts, often with leading institutes in the Netherlands, underscore his ability to integrate chemical biology with clinical applications. For students and researchers, his work exemplifies how mechanistic insights into cellular repair pathways can translate into novel therapeutic strategies, offering a model for translational research in drug discovery.