Jacques Neefjes
Papers
1
Total Citations
32
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1
About
Jacques Neefjes is a pioneering cell biologist whose research illuminates the molecular choreography of antigen presentation, intracellular transport, and immune surveillance. His major contributions center on understanding how cells process and present antigens via MHC class I and II molecules—a cornerstone of adaptive immunity. Neefjes famously elucidated the peptide-loading complex and the role of the proteasome in generating antigenic peptides, work that has profound implications for vaccine design and immunotherapy. His studies on endosomal trafficking and lysosomal function have also reshaped our understanding of cellular homeostasis and disease, including cancer and neurodegenerative disorders. With over 20,000 citations across his career, Neefjes’ impact is immense. Among his notable achievements, he identified a novel ATM inhibitor that selectively radiosensitizes cancer cells, opening new avenues for targeted radiotherapy. A recipient of the Spinoza Prize and member of the Royal Netherlands Academy of Arts and Sciences, Neefjes continues to inspire with his elegant, mechanistic approach to cell biology—bridging fundamental discoveries with translational potential in immunology and oncology.
Research Focus
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Top Papers
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