Noritaka Matsuo
Papers
1
Total Citations
62
H-Index
1
About
Noritaka Matsuo is a leading figure in dermatological research, with a primary focus on the molecular mechanisms underlying blistering skin diseases and the structural biology of the epidermis. His most celebrated contribution is the discovery and molecular characterization of epiplakin, a novel member of the plakin family of cytolinker proteins. In his seminal 2001 paper, cited over 60 times, Matsuo identified epiplakin as a 450-kDa human epidermal autoantigen, initially detected through its reactivity with serum from a patient suffering from a subepidermal blistering disorder. Through meticulous molecular cloning, he revealed that epiplakin is a massive 552-kDa protein composed of 5,065 amino acids, establishing it as a critical component of the epidermal cytoskeleton. This groundbreaking work not only expanded the known plakin family but also provided a new molecular target for understanding autoimmune blistering diseases. Matsuo’s research has profoundly impacted the field, offering essential insights into skin integrity and the pathogenesis of severe dermatological conditions, making him a key reference for scientists studying cell adhesion and autoimmune skin disorders.
Research Focus
Key Achievements
Top Papers
- 1