Mohammed Khaleduzzaman
Papers
1
Total Citations
62
H-Index
1
About
Mohammed Khaleduzzaman is a molecular biologist whose research has significantly advanced our understanding of the plakin family of cytoskeletal linker proteins. His most impactful work centers on the discovery and characterization of epiplakin, a novel and unusually large member of this protein family. In his landmark 2001 study, which has garnered over 60 citations, Khaleduzzaman identified epiplakin as a 450-kDa human epidermal autoantigen, later revealing through molecular cloning that it is a massive 552-kDa protein comprising 5,065 amino acids. This foundational discovery was prompted by its reactivity with serum from a patient suffering from a subepidermal blistering disease, directly linking epiplakin to human pathology. By elucidating the structure and potential function of this giant plakin, Khaleduzzaman provided critical insights into the molecular architecture of the epidermis and the mechanisms underlying certain autoimmune blistering disorders. His work remains a key reference for researchers studying cell adhesion, cytoskeletal dynamics, and the molecular basis of skin diseases, establishing him as an important contributor to dermatological and cell biology research.
Research Focus
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Top Papers
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