David Parry
Papers
1
Total Citations
62
H-Index
1
About
David Parry is a leading figure in structural biology, with a career-long focus on the molecular architecture of intermediate filaments and the plakin family of cytolinker proteins. His major contributions lie in elucidating the complex, large-scale structures of these proteins, which are fundamental to cell integrity and tissue resilience. Parry’s work has profoundly impacted the understanding of skin blistering diseases and other cytoskeletal disorders. His most cited paper, "Epiplakin, a Novel Member of the Plakin Family" (2001, 62 citations), details the discovery and molecular cloning of epiplakin, a massive 552-kDa protein identified as an autoantigen in a subepidermal blistering disease. This seminal study not only characterized a new plakin family member but also provided critical insights into the autoimmunity underlying severe skin fragility. Through decades of research, Parry has established the structural principles governing filament assembly and cross-linking, making him a foundational figure in the field whose work continues to guide investigations into cell mechanics and disease pathology.
Research Focus
Key Achievements
Top Papers
- 1