Naoko Takeo
Papers
1
Total Citations
62
H-Index
1
About
Naoko Takeo is a leading figure in dermatological research, with a primary focus on the molecular architecture of the skin and the mechanisms underlying blistering diseases. Her most significant contribution is the discovery and characterization of epiplakin, a novel member of the plakin family of cytolinker proteins. In her landmark 2001 study, which has garnered 62 citations, Takeo identified epiplakin as a 450-kDa human epidermal autoantigen that reacts with serum from patients suffering from a subepidermal blistering disease. Through meticulous molecular cloning, she revealed that the protein comprises 5,065 amino acids, with a molecular mass of 552 kDa, establishing its role as a critical structural component of the epidermis. This work not only expanded the known repertoire of plakin family members but also provided a new target for understanding autoimmune blistering disorders. Takeo’s research has profoundly impacted the field of dermatology, offering insights into skin integrity and disease pathology that continue to inform both basic science and clinical investigations.
Research Focus
Key Achievements
Top Papers
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