N. Milioti
Papers
2
Total Citations
74
H-Index
2
About
N. Milioti is a structural biologist whose work has significantly advanced our understanding of the molecular machinery of *Bacillus anthracis*, the bacterium responsible for anthrax. Her research centers on structural genomics and high-throughput protein crystallography, with a primary focus on identifying and characterizing essential proteins from this pathogen as potential targets for therapeutic intervention. Her most cited work, the 2005 determination of the crystal structure of dihydrodipicolinate synthase (BA3935) from *B. anthracis* at 1.94 Å resolution (47 citations), provided critical insights into a key enzyme in bacterial cell wall synthesis. This foundational study was part of a larger, collaborative structural proteomics initiative, detailed in her 2006 paper (27 citations), which showcased a high-throughput pipeline for protein structure determination. By combining targeted gene selection based on essentiality studies with rapid crystallographic analysis, Milioti’s contributions have laid the groundwork for structure-based drug design against anthrax, demonstrating the power of integrating genomics with structural biology to address biomedical threats.
Research Focus
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Top Papers
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