Anthony J. Wilkinson
Papers
4
Total Citations
160
H-Index
4
About
Anthony J. Wilkinson is a structural biologist whose research sits at the intersection of protein crystallography, structural genomics, and infectious disease biology. He has made significant contributions to the development and application of high-throughput methodologies for protein structure determination, helping to accelerate the pace at which novel protein structures are characterized and deposited in the Protein Data Bank. His most cited work (74 citations) examines cutting-edge approaches to crystallization and crystal structure determination, reflecting his deep engagement with the technical challenges that underpin modern structural biology. A substantial portion of Wilkinson's research has focused on *Bacillus anthracis*, the bacterium responsible for anthrax and a critical biomedical and biosecurity target. Through the European Structural Proteomics in Europe (SPINE) initiative, he and his collaborators at York and Oxford determined high-resolution crystal structures of essential *B. anthracis* proteins, including dihydrodipicolinate synthase and PurE, enzymes integral to bacterial survival and nucleotide biosynthesis. These structures, resolved to near-atomic resolution, provide foundational insights for antimicrobial drug design. Wilkinson's body of work exemplifies how combining rigorous structural methods with strategic biological targets can yield discoveries with meaningful real-world impact.
Research Focus
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Top Papers
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