N. Kunishima
Papers
2
Total Citations
34
H-Index
2
About
N. Kunishima is a leading structural biologist whose work has significantly advanced high-throughput crystallography and automated ligand screening at the RIKEN SPring-8 Center. His primary research focuses on developing innovative pipeline technologies for protein crystallography, particularly in the automation of crystallization-to-structure determination and ligand-soaking experiments. Kunishima’s major contributions include the design and implementation of a high-throughput crystallization-to-structure pipeline that streamlines the entire process from crystal growth to data collection and structure solution, enabling rapid and efficient protein structure determination. His development of Autolabo, an automated system for ligand-soaking experiments with protein crystals, represents a critical breakthrough for both experimental phasing—by facilitating the preparation of heavy-atom derivative crystals—and for large-scale pharmaceutical ligand screening, reducing labor and human contact risks. These technologies have been widely adopted, with his most-cited paper accumulating 26 citations, reflecting their impact on the structural biology community. Kunishima’s work continues to drive efficiency and safety in macromolecular crystallography, making him a key figure in the automation revolution that has accelerated drug discovery and fundamental biological research.
Research Focus
Key Achievements
Top Papers
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