Michihiro Sugahara
Papers
3
Total Citations
35
H-Index
2
About
Michihiro Sugahara is a leading figure in structural biology and high-throughput X-ray technologies, whose work has revolutionized the automation of macromolecular crystallography. His primary research focuses on developing integrated pipelines for protein structure determination and advanced synchrotron radiation instrumentation. Sugahara’s most impactful contribution is the "high-throughput crystallization-to-structure pipeline at RIKEN SPring-8 Center" (2008, 26 citations), which established a fully automated workflow from crystal growth to data collection, dramatically accelerating structural genomics. He further advanced the field with the "Autolabo" system (2010, 8 citations), an automated platform for ligand-soaking experiments that enables efficient heavy-atom derivative preparation for experimental phasing and large-scale pharmaceutical ligand screening—reducing human error and contact with hazardous materials. Most recently, Sugahara has extended his automation expertise to materials science with the development of a fully automatic high-energy X-ray tomography system at SPring-8 BL28B2 (2024, 1 citation), integrating a sample exchange robot and high-definition camera for seamless measurement and image reconstruction. His work exemplifies the fusion of robotics and synchrotron science, making high-throughput structural analysis accessible for both biological and industrial applications.
Research Focus
Key Achievements
Top Papers
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