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About

Michal Breker is a cell biologist whose research sits at the intersection of cellular proteostasis, cell cycle regulation, and high-throughput genetic screening methodologies. Working across yeast and algal model systems, Breker has made significant contributions to our understanding of how cells manage protein degradation and coordinate cell division. Breker's most impactful work, garnering 89 citations, revealed that the formation and dissociation of proteasome storage granules — specialized compartments housing the cell's primary protein degradation machinery — are governed by cytosolic pH. This finding added an elegant layer to our understanding of how cells regulate proteolysis in response to nutrient stress, particularly glucose depletion. Shifting focus to the green alga *Chlamydomonas reinhardtii*, Breker pioneered robotically assisted, high-throughput screening platforms to systematically identify essential cell cycle genes — work that earned 35 citations and introduced the innovative MAPS-SEQ mutation identification strategy. By developing temperature-sensitive lethal mutant collections, Breker cleverly circumvented the limitations of conventional gene deletion approaches for essential genes. Together, these contributions demonstrate a researcher with a talent for building powerful experimental tools that illuminate fundamental biological processes across diverse model organisms.