Kristi Lieberman
Papers
3
Total Citations
45
H-Index
2
About
Kristi Lieberman is a cell biology researcher whose work centers on uncovering the genetic architecture of cell cycle regulation using the green alga *Chlamydomonas reinhardtii* as a model organism. Her research is distinguished by its innovative integration of high-throughput robotics, mutagenesis techniques, and advanced sequencing methods to systematically identify and characterize essential genes — work that circumvents the fundamental limitations of traditional gene deletion approaches, which cannot target genes critical for survival. Lieberman's most influential contribution is the development of MAPS-SEQ, a novel methodology that resolves a longstanding bottleneck in mutant analysis by efficiently pinpointing causative "driver" mutations within complex genetic backgrounds. This breakthrough, published in 2018 and accumulating 35 citations, enabled a comprehensive discovery of cell-cycle-essential pathways at an unprecedented scale. Her earlier foundational work, beginning in 2016, pioneered a collection of temperature-sensitive lethal mutants, providing the research community with a powerful toolkit for probing essential gene function. With a focused body of work at the intersection of genetics, genomics, and cell biology, Lieberman has made meaningful contributions to our mechanistic understanding of eukaryotic cell cycle control.
Research Focus
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Top Papers
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