Lee Zeev Peters
Papers
1
Total Citations
89
H-Index
1
About
Lee Zeev Peters is a cell biologist whose research centers on the regulation of protein degradation and cellular stress responses, with a particular focus on the 26S proteasome—the cell’s primary machinery for breaking down unneeded or damaged proteins. In a seminal 2013 study (89 citations), Peters employed a systematic robotic screening approach in yeast to uncover that the formation and dissociation of proteasome storage granules (PSGs) are tightly controlled by cytosolic pH. This work revealed a novel mechanism by which cells dynamically sequester proteasomes into granules during glucose depletion, protecting them from degradation and enabling rapid reactivation upon nutrient recovery. By elucidating how pH shifts govern the reversible assembly of these granules, Peters provided fundamental insights into cellular adaptation to metabolic stress. His contributions have advanced understanding of proteasome regulation, with implications for aging, neurodegeneration, and diseases linked to protein homeostasis. Peters’ innovative use of high-throughput screening and his focus on the intersection of metabolism and proteostasis mark him as a rising leader in the field, whose work continues to inspire new avenues for therapeutic intervention.
Research Focus
Key Achievements
Top Papers
- 1