Shay Ben‐Aroya
Papers
1
Total Citations
89
H-Index
1
About
Shay Ben‐Aroya is a leading molecular biologist whose research centers on the cellular mechanisms of protein degradation and stress adaptation, with a particular focus on the 26S proteasome. His major contributions have illuminated how cells regulate proteasome dynamics under environmental stress. In his seminal 2013 work, which has garnered 89 citations, Ben‐Aroya and his team employed a systematic robotic screening approach in yeast to uncover that the formation and dissociation of proteasome storage granules (PSGs) are critically regulated by cytosolic pH. This discovery revealed a fundamental survival strategy: upon glucose depletion, cells sequester proteasomes into PSGs to preserve protein degradation capacity, then rapidly release them when conditions improve. Beyond this landmark study, his research has advanced our understanding of how cells maintain proteostasis during stress, with implications for aging and neurodegenerative diseases. Ben‐Aroya’s innovative use of high-throughput genetic screens has established him as a pioneer in systems-level analysis of protein quality control, making his work essential reading for students and researchers exploring cellular resilience and the molecular logic of stress responses.
Research Focus
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Top Papers
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