Michaela A. McCown
Papers
1
Total Citations
125
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1
About
Michaela A. McCown is a leading figure in the advancement of mass spectrometry-based proteomics, with a primary focus on developing robust, high-throughput workflows for low-input and single-cell analysis. Her most impactful contribution is the creation of a fully automated sample processing and analysis pipeline, detailed in her highly cited 2020 paper (125 citations). This work directly addresses one of the field’s greatest bottlenecks: the manual, error-prone handling of nanoliter-scale samples. By integrating custom fluidics with automated injection, McCown’s system dramatically improves reproducibility and throughput for profiling trace protein samples, from single mammalian cells to clinical biopsies. Her innovations have made deep proteome coverage accessible from previously intractable sample types, accelerating discoveries in cell biology and disease biomarker research. McCown’s work stands as a cornerstone for the next generation of automated, high-sensitivity proteomics, enabling researchers to ask questions at the single-cell level with unprecedented confidence and scale.
Research Focus
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Top Papers
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