Papers
6
Total Citations
387
H-Index
6
About
Ryan Kelly is a pioneering analytical chemist and proteomics researcher whose work has fundamentally transformed the field of low-input and single-cell proteomics. Based at Brigham Young University, Kelly's research focuses on developing ultrasensitive mass spectrometry-based workflows, microfluidic sample handling, and spatially resolved proteome mapping — technologies that address critical bottlenecks in analyzing minute biological samples. Kelly's most celebrated contributions include his development of nanodroplet-based sample processing platforms, enabling spatially resolved protein mapping from laser-capture microdissected tissues with unprecedented sensitivity (141 citations). His fully automated low-input proteomics workflow (125 citations) has become a landmark achievement, allowing researchers to profile protein expression in single mammalian cells without the manual handling that previously limited reproducibility and throughput. His benchtop-compatible workflow for sub-100-cell proteomics (58 citations) further democratized these capabilities for broader laboratory adoption. Beyond methodology, Kelly has championed open-access innovation, adapting commercial pipetting robots for nanoliter liquid handling, lowering barriers for researchers worldwide. His integration of ion mobility mass spectrometry with nanowell separations demonstrates a commitment to multidimensional analytical innovation. Collectively accumulating nearly 400 citations across recent works, Kelly's contributions are reshaping how scientists interrogate tissue heterogeneity and single-cell biology at the proteome level.
Research Focus
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Top Papers
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