Mark R. Chance
Case Western Reserve University, Brookhaven National Laboratory
Papers
2
Total Citations
188
H-Index
2
About
Mark R. Chance is a leading figure in systems biology and structural genomics, whose work bridges proteomics and cancer biology. His research focuses on understanding complex protein interaction networks, particularly in the context of human disease. A major contribution is his development of computational and experimental approaches to map and score protein interaction subnetworks, as demonstrated in his highly cited 2008 study on late-stage human colon cancer (111 citations). This work identified discriminative activity patterns in colonic tissue, providing new insights into disease mechanisms and potential biomarkers. In parallel, Chance has driven innovation in structural genomics, authoring a seminal paper on automated technologies to accelerate protein crystallography (77 citations). His efforts have advanced high-throughput protein structure determination, enabling faster discovery of therapeutic targets. With over 100 publications, Chance’s work has had a lasting impact on both fundamental biology and translational medicine, making him a key figure in the integration of proteomics, network biology, and structural studies.
Research Focus
Key Achievements
Top Papers
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