Babu A. Manjasetty

Brookhaven National Laboratory, European Molecular Biology Laboratory

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About

Babu A. Manjasetty is a leading figure in structural biology, whose work has fundamentally advanced the field of macromolecular crystallography. His primary research focuses on developing automated technologies and innovative methodologies to accelerate the process of protein structure determination, a critical bottleneck in structural genomics. Manjasetty’s most influential contribution is his 2008 paper on automated technologies for protein crystallography, which has garnered 77 citations and serves as a foundational reference for high-throughput structural genomics initiatives. This work addresses the challenge of translating vast genomic data into three-dimensional protein structures by streamlining crystallization and data collection. He is also the architect behind the FlexED8 sample changer, a fast and flexible system introduced in 2017 that revolutionized synchrotron beamline operations. Unlike its predecessors, FlexED8 is compatible with multiple sample holders and pucks, drastically reducing sample-handling time and improving crystal alignment efficiency. With 18 citations, this innovation has become a standard tool for modern crystallography facilities. Through these contributions, Manjasetty has enabled researchers worldwide to solve protein structures more rapidly, accelerating discoveries in drug design and molecular biology. His work remains essential for any scientist seeking to harness automation for structural studies.