Mark Marsden
Papers
3
Total Citations
169
H-Index
3
About
Mark Marsden is a pioneering biomedical engineer whose research sits at the intersection of advanced optics, machine learning, and surgical oncology. His primary focus is the development of label-free fluorescence lifetime imaging (FLIm) to provide real-time, intraoperative guidance for cancer surgery. Marsden’s major contributions include demonstrating that FLIm can accurately delineate tumor margins during oral and oropharyngeal cancer resections, a critical challenge in head and neck oncology. His landmark 2020 study, with 88 citations, validated FLIm’s diagnostic ability using a fiber-based system across 53 patients, analyzing nearly 68,000 measurement points. He further extended this work by integrating FLIm with the da Vinci robotic surgical platform for transoral robotic surgery, a 2019 study cited 54 times, and has applied the technique to solve the difficult problem of detecting unknown primary origins in p16+ oropharyngeal carcinoma. By combining optical biopsy with machine learning, Marsden’s work promises to reduce positive surgical margins and improve patient outcomes, establishing him as a leading innovator in intraoperative imaging and precision oncology.
Research Focus
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