Marco Falletti

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About

Marco Falletti is a movement disorders researcher whose work is reshaping the understanding of rigidity in Parkinson’s disease (PD). His primary research focus lies at the intersection of clinical neurology, biomechanics, and neurophysiology, where he develops objective, instrumented measures to quantify motor signs that have traditionally been assessed only subjectively. Falletti’s most cited paper (2023, 31 citations) provides foundational evidence linking biomechanical and neurophysiological data to the clinical phenomenon of rigidity, addressing a critical gap in PD assessment. He has further advanced the field by demonstrating the velocity-dependent nature of objective rigidity and quantifying the beneficial effects of levodopa on this cardinal sign (2025, 5 citations). His investigation into cogwheel rigidity (2025, 3 citations) offers the first detailed clinical, biomechanical, and neurophysiological characterization of this poorly understood phenomenon, proposing a pathophysiological framework for its interpretation. By bridging engineering precision with clinical neuroscience, Falletti’s work paves the way for more accurate diagnosis, treatment monitoring, and rehabilitation strategies in Parkinson’s disease, establishing him as a rising authority in quantitative movement analysis.