Papers
3
Total Citations
174
H-Index
3
About
Lilian Jacquamet is a structural biologist whose work bridges fundamental molecular mechanisms and cutting-edge crystallographic methods. Her research centers on understanding bacterial gene regulation through metal-dependent protein activation, with a particular focus on the ferric uptake regulator (Fur) from *Escherichia coli*. In her highly cited 2006 study (112 citations), Jacquamet combined NMR and X-ray crystallography to reveal the structural changes that occur during Fur’s metal-dependent dimerization and activation—a critical process for bacterial iron homeostasis and virulence. This work provided key insights into how metal binding triggers conformational shifts that enable Fur to bind DNA and regulate gene expression. Beyond her biological discoveries, Jacquamet has made significant technical contributions to protein crystallography. She pioneered the use of UV laser-excited fluorescence for visualizing protein crystals mounted in loops (41 citations), a method that dramatically improved crystal detection and reduced sample waste at synchrotron beamlines. She also developed a highly integrated sample environment for protein crystallography (21 citations), streamlining the automation of data collection. Her dual expertise in solving biological structures and advancing crystallographic tools has made her a valuable contributor to structural proteomics, helping to overcome bottlenecks in high-throughput structure determination.
Research Focus
Key Achievements
Top Papers
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- 3A new highly integrated sample environment for protein crystallography21 citations · 2004