Yvain Nicolet
Papers
1
Total Citations
112
H-Index
1
About
Yvain Nicolet is a leading structural biologist whose research illuminates the molecular mechanisms of bacterial regulation and metalloprotein function. His work centers on understanding how metal ions control protein structure and activity, with a particular focus on the ferric uptake regulator (Fur) family. In his highly cited 2006 study (112 citations), Nicolet employed a powerful combination of NMR and X-ray crystallography to reveal the structural changes in *Escherichia coli* Fur during metal-dependent dimerization and activation. This landmark work demonstrated how iron binding induces conformational shifts that enable Fur to bind DNA and act as a global bacterial regulator. Beyond this, Nicolet has made significant contributions to elucidating the mechanisms of radical SAM enzymes and hydrogenases, using advanced crystallographic techniques to capture transient reaction intermediates. His research has profound implications for understanding bacterial pathogenesis and developing novel antimicrobial strategies. With a career spanning over two decades, Nicolet continues to push the boundaries of structural biology, providing atomic-level insights into how metalloproteins sense and respond to their environment.
Research Focus
Key Achievements
Top Papers
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