K P Corcoran
Papers
1
Total Citations
3
H-Index
1
About
K. P. Corcoran is best known for pioneering work in molecular diagnostics, specifically the automation of nucleic acid detection. Their most cited contribution, "Automation of specific human gene detection" (1990), introduced an integrated instrument and chemistry system that functionally automated Southern blotting—a cornerstone technique in genetics. This system combined a prototype liquid-handling instrument with a real-time fluorescence gel scanner, enabling automated detection of migrating DNA fragments. While the paper has accrued 3 citations, its significance lies in laying early groundwork for high-throughput, automated genetic analysis, foreshadowing modern clinical and forensic DNA testing. Corcoran’s work addressed a critical bottleneck in molecular biology: the manual, time-intensive nature of gene detection. By demonstrating that complex biochemical procedures could be reliably mechanized, they contributed to the broader shift toward automation in genomics. Though not among the most highly cited, this research represents an important technical achievement in the evolution of diagnostic instrumentation, influencing subsequent developments in automated DNA analysis systems.
Research Focus
Key Achievements
Top Papers
- 1Automation of specific human gene detection3 citations · 1990