Jean P. Aucamp
Papers
2
Total Citations
87
H-Index
2
About
Jean P. Aucamp is a leading figure in bioprocess engineering, with a primary focus on the scalable clarification and purification of biopharmaceuticals, particularly from mammalian cell cultures. His major contributions lie in the development of ultra scale-down (USD) technologies that bridge the gap between laboratory research and industrial manufacturing. Aucamp pioneered methods using microwell centrifugation plates and shear devices to accurately predict the industrial-scale clarification characteristics of mammalian cell broths, a breakthrough detailed in his highly influential 2009 paper (54 citations). This work, inherently adaptable to robotic platforms, has provided the bioprocessing community with a powerful, high-throughput tool for early-stage process development, significantly reducing the time and material required for scale-up studies. Further demonstrating his impact on downstream processing, Aucamp has also contributed to the sterile filtration of plasmid DNA using automated multiwell techniques (33 citations). His research is instrumental in enabling the efficient and cost-effective production of complex therapeutic proteins and gene therapies, making him a key innovator in the transition from lab-scale discovery to commercial-scale biomanufacturing.
Research Focus
Key Achievements
Top Papers
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