A. Bugeon
Papers
1
Total Citations
54
H-Index
1
About
A. Bugeon’s research centers on bioprocess engineering, with a particular focus on the scalable clarification of mammalian cell cultures—a critical step in industrial biotechnology and therapeutic protein production. Their most cited work, “Ultra scale‐down prediction using microwell technology of the industrial scale clarification characteristics by centrifugation of mammalian cell broths” (2009, 54 citations), introduces a pioneering method that combines an ultra scale-down (USD) shear device with a microwell centrifugation plate. This approach enables accurate prediction of how cell broths will clarify at industrial scale, using only microliter volumes. Notably, the method is designed for integration with robotic platforms, offering high-throughput, cost-effective process development. Bugeon’s contributions bridge the gap between laboratory-scale experimentation and full-scale manufacturing, significantly reducing the time and resources needed for bioprocess optimization. By providing a reliable, miniaturized tool for predicting centrifugation performance, their work has advanced the efficiency of downstream processing in the biopharmaceutical industry, making it an essential reference for researchers and engineers working on cell culture clarification and scale-down models.
Research Focus
Key Achievements
Top Papers
- 1