A. Sasha Tait
Papers
2
Total Citations
88
H-Index
2
About
A. Sasha Tait is a leading figure in bioprocess engineering, with a research focus on the scalable manufacture of biotherapeutics, particularly using mammalian cell culture. Her major contributions lie at the intersection of high-throughput screening and process characterization, where she has pioneered methods to accelerate the development of industrial cell lines and downstream processing. Her most cited work, "Ultra scale‐down prediction using microwell technology of the industrial scale clarification characteristics by centrifugation of mammalian cell broths" (2009, 54 citations), introduced a groundbreaking approach to predict large-scale centrifugation performance using miniature, robotic-friendly systems. This work has had a lasting impact on the field by enabling faster, more cost-effective process design. Additionally, her earlier paper on "High‐throughput clonal selection of recombinant CHO cells using a dominant selectable and amplifiable metallothionein‐GFP fusion protein" (2002, 34 citations) provided a novel method to rapidly isolate high-producing cell lines, a critical bottleneck in biomanufacturing. Tait’s work is notable for bridging the gap between laboratory-scale development and industrial implementation, making her a key contributor to modern bioprocess intensification.
Research Focus
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Top Papers
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