Hsi-Hsun Lin

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About

Dr. Hsi-Hsun Lin is a pioneering radiochemist whose work has significantly advanced the field of positron emission tomography (PET) tracer development. His key research areas include automated radiosynthesis, fluorine-18 radiochemistry, and the production of neuroimaging agents. Dr. Lin’s most notable contribution is his seminal 2000 paper on the robotic synthesis of 6-[18F]fluoro-L-dopa (6-[18F]FDOPA), a critical tracer for studying dopamine metabolism in neurological disorders such as Parkinson’s disease. This work, which has accumulated 16 citations, introduced a semi-automated method using the Scanditronix Anatech RB III robotic system, dramatically improving the reproducibility and safety of FDOPA production. By integrating cyclotron-produced [18F]fluorine via the 20Ne(d,alpha)18F reaction, Dr. Lin’s approach reduced manual handling and enabled more reliable tracer synthesis for clinical and research applications. His contributions have laid the groundwork for modern robotic radiochemistry, facilitating broader access to essential PET tracers. Dr. Lin’s dedication to automation and precision continues to influence radiopharmaceutical development, making him a respected figure in molecular imaging and nuclear medicine.