C S CHTSAI

National Yang Ming Chiao Tung University

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About

Dr. C. S. Chitsai is a pioneering radiochemist whose work has significantly advanced the field of positron emission tomography (PET) tracer development. Their key research area centers on the automated synthesis of radiolabeled biomolecules for neurological imaging, with a landmark contribution being the semi-automated robotic synthesis of 6-[18F]fluoro-L-dopa (6-[18F]FDOPA). In their seminal 2000 study, which has garnered 16 citations, Dr. Chitsai developed a method using a Scanditronix Anatech RB III robotic system to produce this critical tracer for dopamine pathway imaging. By integrating cyclotron-produced [18F]fluorine via the 20Ne(d,alpha)18F reaction, they streamlined a previously complex radiosynthesis, enhancing reproducibility and safety in clinical radiochemistry. This work laid the foundation for more accessible production of 6-[18F]FDOPA, a vital tool for studying Parkinson’s disease and other neurodegenerative disorders. Dr. Chitsai’s contributions exemplify the intersection of automation and radiochemistry, enabling broader adoption of PET imaging in both research and clinical settings. Their efforts continue to inspire innovations in tracer synthesis, underscoring the importance of efficient, reliable methods in molecular imaging.