H. Sandmaiser

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About

H. Sandmaiser is a pioneer in the development of high-throughput microarray fabrication technologies, with a primary focus on non-contact printing methods for genomic and proteomic applications. Their most notable contribution is the invention of the TOPSPOT method, introduced in their 2002 landmark paper (29 citations). This innovative technique utilizes a micromachined print head featuring up to 96 vertical nozzles, enabling highly parallelized, non-contact deposition of droplets as small as 1 nanoliter. By eliminating the need for physical contact between the print head and substrate, TOPSPOT dramatically improves reproducibility, reduces cross-contamination, and accelerates the production of microarrays—a critical tool for large-scale gene expression and diagnostic studies. Sandmaiser’s work has been instrumental in advancing the precision and scalability of microarray manufacturing, directly impacting fields from molecular biology to personalized medicine. Their contributions are recognized as foundational in the evolution of lab-on-a-chip technologies, and their method remains a reference standard for researchers seeking reliable, high-density array production.