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About

Ehsan Atefi is a biomedical researcher whose work sits at the intersection of biomaterials engineering, microfluidics, and cancer biology, with a particular focus on developing innovative three-dimensional cell culture technologies for drug discovery applications. His most significant contribution lies in pioneering the use of aqueous two-phase systems (ATPS) for the high-throughput production of tumor spheroids — microscale, three-dimensional cancer cell clusters that more faithfully mimic the architecture and behavior of avascular tumors than traditional flat cell cultures. His landmark 2014 paper on polymeric aqueous two-phase printing of tumor spheroids, which has garnered 93 citations, introduced a precise microprinting technique that deposits submicroliter droplets of cell-containing solutions to generate spheroids at scale, dramatically accelerating the pipeline for anti-cancer drug screening. Complementary studies optimizing this biphasic microtechnology and detailing robotic production protocols — accumulating over 100 additional citations — further cemented his influence in the field. By enabling reproducible, scalable, and biologically relevant 3D tumor models in standard 96-well plate formats, Atefi's research has provided the cancer research community with powerful tools to improve preclinical drug testing accuracy and efficiency.