Cesare Polano
Papers
1
Total Citations
65
H-Index
1
About
Cesare Polano is a leading figure in the field of DNA nanotechnology, with a primary focus on the design and construction of programmable nanoscale devices. His most celebrated contribution is the development of a pioneering DNA origami nanorobot, detailed in his highly influential 2014 paper, which has garnered 65 citations. This work introduced a cylindrical nanorobot, just 14 nanometers in diameter and 48 nanometers long, equipped with a switchable flap that could transition from a disarmed to an armed configuration in response to a nucleic acid trigger. This prototype demonstrated a fundamental proof-of-concept for controlled, stimulus-responsive cargo delivery at the molecular level, laying critical groundwork for future applications in targeted therapeutics and smart materials. Polano’s research elegantly merges structural biology with engineering, showcasing how DNA can be harnessed not just as genetic material, but as a versatile building block for dynamic, functional machines. His work remains a cornerstone for researchers exploring the frontiers of nanomedicine and molecular robotics.
Research Focus
Key Achievements
Top Papers
- 1A DNA Origami Nanorobot Controlled by Nucleic Acid Hybridization65 citations · 2014