Caterina Holz
Papers
2
Total Citations
49
H-Index
2
About
Caterina Holz is a molecular biologist whose work has significantly advanced the understanding of protein expression systems and microbial pathogenesis. Her key research areas include high-throughput cDNA library construction, yeast expression systems, and the functional characterization of integral membrane proteins. Holz’s most notable contribution is the development of a pioneering technique for generating human cDNA expression libraries in *Saccharomyces cerevisiae*, which enables the efficient selection of clones containing open reading frames (ORFs). This work, published in 2001 and cited 35 times, provided a powerful tool for functional genomics and protein interaction studies. She further applied her expertise to the pathogen *Helicobacter pylori*, where she conducted expression screening of its integral membrane proteins—a class that constitutes roughly one-quarter of the bacterium’s proteome. This research, cited 14 times, shed light on the molecular mechanisms behind *H. pylori*’s survival in acidic gastric environments and its colonization success. Holz’s contributions have been instrumental in bridging the gap between gene discovery and protein function, offering valuable resources for both basic research and therapeutic target identification.
Research Focus
Key Achievements
Top Papers
- 1A Human cDNA Expression Library in Yeast Enriched for Open Reading Frames35 citations · 2001
- 2