Stephen E. Wright
Papers
1
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31
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1
About
Stephen E. Wright is a leading researcher in the field of drug transport and pharmacokinetics, with a particular focus on the mechanistic role of P-glycoprotein (P-gp) in multidrug resistance. His work bridges fundamental biochemistry and applied pharmacology, most notably through his highly cited 2012 study, "Determining P-glycoprotein–drug interactions: Evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers." This paper, which has garnered over 30 citations, established a robust dual-method framework for assessing how drugs interact with P-gp, combining a purified liposomal system with a cell-based monolayer model. By validating these complementary approaches, Wright provided researchers with a more reliable toolkit for predicting drug efflux and bioavailability, directly impacting the development of safer, more effective therapeutics. His contributions are essential for understanding transporter-mediated drug disposition and for designing strategies to overcome chemoresistance in cancer treatment.
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