Donald L. Melchior
Papers
2
Total Citations
38
H-Index
2
About
Donald L. Melchior is a biophysicist whose research centers on membrane transport proteins, particularly those involved in multidrug resistance. His major contributions lie in developing innovative liposomal and cell-based assays to study how P-glycoprotein (P-gp) and other transporters interact with drugs and inhibitors. His most cited work, "Determining P-glycoprotein–drug interactions: Evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers" (2012, 31 citations), provides a foundational framework for assessing drug-transporter binding, offering a critical tool for pharmaceutical development. Melchior further advanced the field with "A liposomal method for evaluation of inhibitors of H+− coupled multidrug transporters" (2015, 7 citations), extending his methodology to proton-coupled systems. His work bridges basic biophysics and applied pharmacology, enabling more accurate prediction of drug efficacy and toxicity. By creating robust, reproducible systems for studying transporter function, Melchior has helped clarify mechanisms of drug resistance—a key challenge in cancer therapy. His achievements underscore the importance of membrane biophysics in translational medicine, making his research essential for students and researchers tackling drug delivery and resistance.
Research Focus
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