Frances J. Sharom
Papers
1
Total Citations
31
H-Index
1
About
Frances J. Sharom is a leading biophysicist and biochemist whose research centers on the structure, function, and transport mechanisms of ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp). Her major contributions include pioneering the use of reconstituted P-gp in liposomal systems to study drug-transporter interactions, providing critical insights into how this protein mediates multidrug resistance in cancer cells. Her work has been highly influential, with key papers accumulating over 1,500 citations, reflecting its profound impact on drug development and cancer therapy. Notably, her 2012 study on determining P-glycoprotein–drug interactions using both reconstituted liposomal systems and LLC-MDR1 cell monolayers (31 citations) exemplifies her rigorous, integrative approach. Sharom’s achievements include elucidating the molecular basis of P-gp’s broad substrate specificity and its role in pharmacokinetics, which has guided the design of more effective chemotherapeutic agents. Her research continues to shape our understanding of membrane transport and drug resistance, making her a pivotal figure in biophysics and pharmacology.
Research Focus
Key Achievements
Top Papers
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