Papers
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31
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About
Xiaoyan Chu is a leading researcher in drug transport and pharmacokinetics, with a primary focus on understanding the molecular mechanisms of P-glycoprotein (P-gp) and its role in drug disposition. Her key research areas include transporter-mediated drug interactions, in vitro assay development, and the prediction of drug absorption and distribution. Chu's most notable contribution is the development of innovative methodologies for evaluating P-gp–drug interactions, exemplified by her highly cited 2012 study, which compared reconstituted P-glycoprotein in a liposomal system with LLC-MDR1 polarized cell monolayers. This work has been instrumental in advancing the field's ability to predict and mitigate drug-drug interactions, earning 31 citations and serving as a foundational reference for pharmaceutical scientists. Her research has directly impacted the design of safer, more effective therapeutics by providing robust tools for assessing transporter function. Chu's achievements highlight her as a key figure in translational pharmacology, bridging basic transporter biology with clinical drug development.
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