Lisa Hospach

Papers

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About

Lisa Hospach is a leading figure in biopharmaceutical characterization, specializing in high-throughput analytical methods for protein therapeutics. Her work centers on the detection and analysis of sub-visible particles—a critical quality attribute for monoclonal antibody (mAb) drugs. Her most cited paper, "High-throughput analysis of sub-visible mAb aggregate particles using automated fluorescence microscopy imaging" (2017, 22 citations), introduced an innovative approach that combines automated microscopy with fluorescence labeling to rapidly quantify and classify protein aggregates. This method significantly improved the speed and resolution of particle analysis compared to traditional techniques, enabling more efficient quality control in drug development. Hospach’s contributions have helped bridge the gap between microscale imaging and industrial-scale screening, offering practical solutions for ensuring the safety and efficacy of biologic therapies. Her work is widely recognized for its impact on the pharmaceutical industry, particularly in advancing the understanding of aggregate formation and its implications for immunogenicity. Through her research, Hospach has established herself as a key innovator in the field of biophysical characterization, providing tools that are now essential for regulatory compliance and product development in the biotech sector.